Updated: Jan 1
What is a Stem cell?
Stem cells are specialized human cells that have the ability to develop into many different cell types, from muscle cells to brain cells. More importantly, they are also able to repair damaged tissues.
Aging Stem Cell, Aging Body
The fact that all cells have half-lives and their natural expiration must be matched by their replacement, with the stem cells as the suggested source of these new replacement cells.
When grouped by decade, a dramatic decrease in MSCs per nucleated marrow cell could be observed, with a 10-fold reduction from birth to teens and another 10-fold decline from teens to the elderly. These decreases paralleled the observed fracture healing rates: very rapid in the young and very slow in older patients.
As a result of Stem cell degeneration, our body organ has a malfunction and the aging process as the route cause of disease such as cancer, cardiovascular disease, diabetic, etc.
Stem Cells Replacement as a Therapeutic Treatment
MSCs could be used therapeutically as allogeneic cells, a so-called ‘universal cell,’ a cell that could function in any host. To support this suggestion, it was further documented that culture-expanded MSCs did not have MHC class II cell surface markers, but rather only MHC class I and no co-stimulator molecules. Thus, human Stem cells could not be antigen-presenting cells and would be invisible to the host’s immune system.
MSCs could differentiate into any number of types of cells led, for example, cardiac, muscle, cartilage, etc. So this could be therapeutically useful in sites of cardiac ischemia (infarct) where a large number of cardiac myocytes expire (apoptosis) due to the ischemia; the replacement of these expired cells would be expected to provide clinical benefit.
by Dr. Chontirot Srikasedsarakul
Dr. Chontirot Srikasedsarakul is a specialist in Genomics, Dermatology and Aesthetics. She has received qualifications from numerous educational institutions like Stanford University, U.S.A.; the University of Queensland, Australia; Chulalongkorn University, Thailand and the American Board of Anti-Aging Medicine.