Cartilage problems are among the most common problems in bone and joint problems. Left untreated, may result in the development of osteoarthritis, with a big impact on the quality of life in the long term. The present-date treatment such as microfracture, autologous chondrocyte implantation has shown only a modest degree of success. Despite the variety of available techniques, the effectiveness of these in terms of preventing or delaying the development of osteoarthritis is q

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