What are stem cells?
Stem cells are a specific type of cell, which has several unique abilities. These can be grouped into three primary categories:
Their ability to multiply themselves. One stem cell can duplicate into two daughter cells. This process can happen repetitively to create a cell population for self-repairing systems in our bodies. For example, when we get a laceration, the skin stem cells will multiply as part of the wound healing process to create new skin, thus returning proper function to our body again.
Their ability to transform themselves into a variety of cell types. This is the answer to the question, "why are stem cells a multipurpose treatment for our body?" Under the influence in the right environment, stem cells can transform into multiple cell types that your body needs. An example is Umbilical cord stem cells multiply and transform themselves into nerve cells, muscle cells, blood cells, bone cells, etc. When our body has an injury, stem cell uses their specific mechanism called "homecoming" and travel from their source to the injured organ to start a tissue repairing cascade.
Their ability to renew tissue that they populate by multiple mechanisms such as becoming the dominant cells in injured tissue is an essential factor for healing. Stem cells act as a provider and stimulator for the repairing and rejuvenation process, as is the conductor in an orchestra band.
Stem cells are essential in our life from the moment of conception right up until the moment of our death. In the beginning, embryonic stem cells multiply and transform into multi-organ systems, thus building our new body. Throughout our lives, cells in all parts of our body die and need to be replaced by the stem cells regeneration process. Without stem cells, we can't survive. When our stem cells are impaired, we get sick, when our stem cells age, we age as well. Stem cells are often considered the single most vital part of our body.
The causes of knee problems
Our body is a delicate creation that requires multiple systems and types of tissue to perform in harmony if we want it to work well. Our knee is a complex hinge joint that allows our leg mobile in multiple directions while maintaining the ability to carry our entire body weight. Over the years, the knee is stressed; when we walk, run, jump, etc. our knee helps us stabilize and carries our body weight. Especially when we jump, the force applied to the knee can be up to 10 times our body weight. Even when we sit, we are flexing our knee, which results in more pressure on the joint. Here is an example of the cause of knee problems
Knee and knee component injury such as ligament and tendon injury or torn meniscus or bone fracture
Aging factors as osteoarthritis is a wear and tear disease
Autoimmune disease such as rheumatoid arthritis causing inflammation and destroying knee joints (3)
Knee pain treatment options
Generally, knee pain is the most challenging problem with knee diseases, whether from an acute knee injury or a chronic illness like osteoarthritis. People who have knee pain problems will seek treatment following their knowledge and their ability to access a specific procedure. The treatment option for knee pain can be classified according to the joint destruction process as below.
Knee destruction prevention treatment
The best way to treat any disease is prevention. As osteoarthritis of the knee is a wear and tear issue, lifestyle modification to decrease the workload for knees is essential for disease prevention or hinder disease progression. For example, reduce weight for overweight patients, exercise supportive muscles for the knee, and avoid postures that stress knee joints.
Supportive treatment for pain symptoms
The majority of the procedures for knee problems fall into this category. The root cause of pain comes from inflammation. Many factors can trigger this inflammation; for example, at one stage of osteoarthritis, the protective layer of cartilage breaks down the bone rubbing together, causing swelling and pain. In this case, most treatments only offer temporary pain relief. Furthermore, some medications have been known to cause adverse effects when used long term without proper use such as NSAID pain killers, intra-articular steroid injections that can cause kidney damage or knee-tendon fragility.
Knee replacement therapy
Like a chair, when one leg is too broken to fix, we must replace it. The problem is our body structure is too delicate. Generally, there are still no artificial limbs that can work well and synchronize themselves with our bodies. That why the best treatment for knee problems is prevention. Knee replacement can cause many types of complications. The rate of complications depends on the surgeon and the setting such as infection, nerve injury, restriction of movement, persistent pain, and dissatisfaction. (4)
Stem cell treatment for knee mechanism
Among all treatments currently available, stem cells treatment is one of the best options because it answers all goals that a patient requires:
Relief of painful symptoms. Of Revival Clinic Bangkok's patients, 100% said they would recommend people who have the same problem do stem cell treatment.
Knee destruction prevention. Slows down disease progression to avoid knee replacement therapy.
Repair the injured knee component structure such as tendons, cartilage, and other multiple cell components of the knee joint.
Stem cell injections help enhance naturally anti-inflammatory agents, such as cytokines and contain essential growth factors that help stimulate tissue growth.
Thanks to the unique properties of stem cells, they will: (5)
Develop into essential cartilage cells
Produce proteins called cytokines that slow degeneration of cartilage and reduce pain
Prevent the inflammation that can worsen arthritis
Stem cell treatment for knee injuries at Revival Clinic Bangkok
This new cell therapy method is highly effective and evidence-based.
The stem cell therapy for knees does not require surgery or overnight hospital stays, and patients can return to daily life following the procedure. This is also beneficial by avoiding the risk of lengthy and painful rehabilitation needed after invasive knee joint surgeries. Especially for the elderly, the longer inactive duration after surgery increases the risk of
complications in another organ system.
All procedures will be done by an orthopedic surgeon who delivers stem cells to your knee using a minimally invasive method of intra-articular injection.
What are the types of stem cells we use and why?
There are three major types of stem cells.
Embryonic stem cells are generally only used for the research as they have been linked with tumor generation.
IPSC Stem cells from genetic engineering, are also still in the research phase. Also showing some links to cancer production
Adult stem cells, the most commonly used cells for therapeutic procedures, are not linked with tumor or cancer risks. There are a variety of sources of adult stem cells, for example, from the umbilical cord, liposuction, menstrual blood, etc.
The type of stem cells that we use at Revival Clinic Bangkok are adult stem cells from the umbilical cord. The reason that we choose this source is that stem cells, like the other cell in our body, age with you. Umbilical cord stem cells come from the cells from when we are born, i.e., age 0! The younger the cell, the better the efficacy of treatment.
Umbilical cord stem cells are easy to access and require no surgery for harvesting. Umbilical cord stem cells have a specific property called Immune privilege, making them a universal donor.
What is the price of stem cell treatment for the knee in Bangkok?
According to our online research team, we found the price of similar treatments to be as follows
In the large hospitals, 300,000 THB per knee. This fee does NOT include consultation and examination fees.
500,000 THB for both knees with ten days medical package, at another Bangkok clinic
Another clinic was advertising at 270,000 THB per knee
To further confuse the issue some clinics are misrepresenting platelet-rich plasma (PRP) treatments as PRP stem cells and offering that for 39,000 THB
What is the price of stem cell treatment for knee at Revival Clinic?
Our price is
145,000 THB per knee
270,000 THB both sides
This price includes everything you need for this treatment; there is no hidden charge. We absorb all fees such as doctor fees, vat, specialist nurse, private Van transportation, and orthopedist fee.
We use stem cells from the best lab at a fraction of the price. This means your money will focus on attaining you the best quality stem cells available!
Duration of stay.
The minimum length to stay in Bangkok for stem cell treatment for the knee is three days.
For your convenience, we have free transportation to and from your hotel.
The lab that we use.
Our lab produces mesenchymal stem cells from cord tissue. All cells produced are generated according to EU GMP rules, SO, and conform to general MSC criteria. We use the same lab as big hospitals at a fraction of the price.
We recommend you avoid strenuous exercise or exercise that may cause injury such as skiing to prevent any other interfering with your stem cell treatment. As stem cells have homecoming properties, we want them to focus on repairing your knee and not be distracted by new injuries.
Since our stem cell treatment for knees is a local injection, the downtime is minimal.
We recommend you rest for the first 24 hrs. Try to walk only if necessary.
Strenuous exercise associated with knees such as jumping, jogging should be avoided for a month. Walking or daily life activity can usually resume 24hrs after injection.
How effective is stem cell therapy for the knee?
All of our customers have had knee pain reduction and improved quality of life after treatment. Canadian research shows that degeneration of the knee is vastly improved with this therapy.
We have 100% customer satisfaction, and all customers want to recommend this treatment to their acquaintances who have the same problem.
You can read more research about stem cell treatment's effectiveness via this link https://www.revivalclinicbangkok.com/post/arthritis-in-the-knee-is-truly-crippling
Are Stem Cell Treatments Safe?
Mesenchymal Stem Cell Therapies treatment for blood disease has been used for over 45 years now and is a very safe, effective alternative therapy. At Revival Clinic Bangkok, we choose our stem cells from the best lab sources that the large private hospitals use, at a fraction of the price. We have never had a single case that reported adverse side effects.
Things to know before deciding to treat your knee with stem cells in Bangkok
Misleading marketing about stem cells on the internet
At Revival Clinic Bangkok, we understand that researching the information on the internet is challenging for the customer. Our market research team found an overwhelming amount of content on the web about stem cells. It is difficult for non-health care professionals to see the facts behind a misleading campaign.
We found places offering PRP (platelet-rich plasma from blood spinning method) with high pricing and calling it to stem cells
There is a vast difference between stem cells, which are new cells cultivated from biological laboratories and PRP extracted from patient's blood in both cost and effectiveness.
A luxury setting doesn't guarantee good quality.
According to an article about stem cell fraud in Thailand from Thailand Medical news (6), many clinics, especially the hi-end areas like Sukhumvit offer stem cell treatment in a luxury setting without having a certified doctor on site. Some places use Doctors that have graduated from outside Thailand, such as the Philippines or even just a nurse. This against Thai law. If you receive a treatment at a facility without proper credentials, there will be nobody to take responsibility for any side effects or the consequences.
As we are specialized in this business, we have heard about all the tricks and the negative consequences of an illegal setting or malpractice.
Our suggestion is to do more research about the clinic, not only believe what you see on the marketing side. Stem cells are a proper and effective treatment only in the right place and with the correct knowledge.
Do more cells mean a better result?
As with other treatments, factors that may affect efficacy are the route of injection, number of cells, and most importantly, the cell quality; because of this, we often have patients' asking about the number of cells compared with the price. More cells do not necessarily mean a better result. One thing that we know about stem cells is it has the property of self-multiplication. Good quality stem cells can multiply inside the body, while lower quality stem cells will quickly die, leaving millions of cells for our body to eradicate, which may, in turn, cause illness.
1. 1.Mark L. Weiss and Deryl L. Troyer," Stem Cells in the Umbilical Cord" Stem Cell Rev. 2006; 2(2): 155–162.
2. Imran Ullah Et Al. Human mesenchymal stem cells - current trends and future prospective. Biosci. Rep. (2015)
3. Mayo clinic "knee pain" https://www.mayoclinic.org/diseases-conditions/knee-pain/symptoms-causes/syc-20350849
4. GP online "complication after knee replacement injury" https://www.gponline.com/complications-total-knee-replacement-surgery/musculoskeletal-disorders/rheumatoid-arthritis-other-autoimmune-disorders/article/1209527
5. Medically reviewed by William Morrison, MD on August 21, 2018 — Written by Jennifer Leavitt, MS. "Can stem cell therapy repair the damage knee" Healthline
6. Thailand Medical News 21 October 2019 "Certain clinic in Thailand offer fraudulent stem cell treatment"