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Pathological of back pain 

Back pain is a prevalent complaint that can profoundly affect an individual's quality of life, especially when it comes to lower back pain. The lower back, consisting of just five vertebrae compared to the neck and mid-back, plays a vital role in supporting the upper body and connecting the spine to the pelvis. Given its constant involvement in weight-bearing and a wide range of movements, this region is susceptible to wear, tear, and injuries, contributing to the challenges individuals may face in their daily lives.

The pathology of back pain can arise from various sources, including sudden injuries resulting from accidents. It's worth noting that these accidents don't necessarily have to be high-trauma events; even a small twist on an unlucky day can cause damage to the back. Another common cause is the gradual degeneration of spinal joints, often identified as the most frequent culprit behind lower back pain.

 

As we age, wear and tear are inevitable, and it's normal for the lower back to exhibit signs of distress over time. The breakdown of cartilage between spinal joints may trigger inflammation in the surrounding tissues. This inflammation, combined with the thinning of cartilage, intensifies friction in the joints, leading to pain in the lower back. The degenerative changes in the intervertebral disk can further contribute to structural alterations, biomechanical instability, inflammation, and nerve ingrowth, collectively influencing the complexity of back pain.

Standard therapeutic approaches, such as lumbar fusion surgery, have demonstrated the potential to alleviate pain in certain individuals. However, it is crucial to acknowledge that the effectiveness of these treatment modalities can exhibit variations among individuals and may, in some cases, diminish over time. The controversy surrounding standard treatments emphasizes the need for a comprehensive evaluation of each patient's unique condition and consideration of alternative or complementary approaches that align with the latest research findings.

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Mesenchymal stem cell treatment for back pain 

Mesenchymal stem cell treatment for back pain stands as a safe and effective therapeutic option, supported by the evolving landscape of regenerative medicine. Integrating cutting-edge tissue-engineering technologies and biomaterials science, stem cell-based therapies have emerged as fundamental pillars in the field. 

The utilization of stem cells in regenerative therapy has provided valuable insights into potential therapeutic avenues for addressing discogenic back pain, further emphasizing the potential safety and efficacy of this innovative treatment approach.

At Revival Clinic, our back stem cell treatment is a streamlined process, featuring a simple intramuscular injection of mesenchymal stem cells sourced from umbilical cord tissue. Our approach leverages the homing effect mechanism of stem cells, directing them to the specific site of pain and inflammation. This targeted strategy aims to maximize the regenerative potential of these cells, ensuring both safety and effectiveness throughout the treatment process.

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Had been thinking about getting Stem Cell therapy for many years now but couldn’t find the right place. But all was answered after getting in touch with Revival.

 

I spoke to George and we came up with a plan to help increase mobility and decrease the severe pain in my ankle.

 

He was brilliant along with all the staff, they all made me feel very comfortable and at ease during the procedure. It was swift and simple. I’m already feeling a big difference!

 

I’m glad I took the leap of faith and came to Revival for my treatment!

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I'm feeling great. My back has shown the most improvement so far ( which needed it the most ). For the first time in over 10 years I've been able to sleep on my stomach comfortably. My knee feels much better and aside from drinking myself stupid, my mental clarity has improved significantly with an improvement to my anxiety. 

Our patient story 

Let me share a compelling patient story that underscores the transformative impact of stem cell treatment. Meet Sarah, a dynamic, high-achieving executive in her late 30s, commanding a substantial income in her demanding job. The nature of her executive role kept her tethered to her desk for prolonged periods, coupled with the challenge of being overweight over time, triggering persistent low back pain.

Sarah, determined to find relief, embarked on an exhaustive journey through various medical avenues, including hospital treatments and alternative therapies like acupuncture. However, the relentless pain persisted, leading her doctors to prescribe increasingly potent painkillers. Unfortunately, this well-intentioned approach led to an unforeseen complication—gastritis, adding another layer of discomfort to her already challenging situation.

Complicating matters further, Sarah, driven by the demands of her high-responsibility job, found it impossible to take a hiatus to address her health concerns adequately. The pain became so severe at times that she felt on the verge of fainting. An MRI revealed mild osteoarthritis in her spine, thankfully nothing that warranted surgery. The conventional medical approach persisted, with stronger painkillers and recommendations for weight reduction, a challenging prospect given that every attempt to exercise exacerbated her pain.

Driven by her relentless pursuit of a solution, Sarah delved into intensive research on stem cell treatment. Her quest led her to us, and the injection procedure went smoothly. Miraculously, just a day after the treatment, Sarah experienced a remarkable 50% relief from her back pain. Not only did her pain diminish, but her overall quality of life improved, and she regained the joy of uninterrupted sleep, free from the throes of back pain.

Today, Sarah is gradually reintroducing exercise into her routine, a testament to the efficacy of stem cell treatment in not only alleviating pain but also restoring the vitality and resilience needed to navigate life's demands. Her journey exemplifies the power of innovative medical approaches in restoring hope and well-being."

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Commonly employed treatments for disc degeneration include:

Conservative Management:

  • Physical therapy to improve strength and flexibility.

  • Pain medications and anti-inflammatory drugs.

  • Lifestyle modifications, such as weight management and avoiding prolonged sitting.

Interventional Procedures:

  • Epidural steroid injections to reduce inflammation and alleviate pain.

  • Facet joint injections for pain relief.

  • Radiofrequency ablation to disrupt nerve signals and reduce pain.

Surgical Options:

  • Discectomy: Removal of part of a disc.

  • Spinal fusion: Joining two or more vertebrae together.

  • Artificial disc replacement: Replacement of a damaged disc with an artificial one.

As of now, there is a lack of definitive solutions for disc degeneration.

According to the study titled "One-year Outcomes of Surgical versus Non-surgical Treatments for Discogenic Back Pain: A Community-based Prospective Cohort Study," authored by Sohail K. Mirza, MD, MPH, Richard A. Deyo, MD, MPH, Patrick J. Heagerty, PhD, Judith A. Turner, PhD, Brook I. Martin, PhD, and Bryan A. Comstock, MS. The study was conducted as a community-based prospective cohort study and is available under the publication information provided below

 

The study looked at treatments for discogenic back pain and found that both surgery and non-surgical approaches had modest outcomes. Patients seeking surgery had moderate pain and disability levels, and those who had surgery along with other treatments showed some improvement compared to those continuing non-surgical care. However, only a third of surgical patients achieved a successful outcome, and surgery was associated with increased restrictions and opioid use. Non-surgical care, often not following guidelines, showed minimal improvement. The study suggests that even basic conservative care may lead to significant improvements, highlighting the challenges of treating discogenic back pain.

Possible complication from surgery
  • Infection:

  • Infections can occur at the surgical site or in the spine itself.

  • Bleeding:

  • Excessive bleeding during or after surgery can occur, requiring further intervention.

  • Nerve Injury:

  • Nerve damage can lead to sensory or motor deficits. The risk depends on the surgery's complexity and proximity to nerves.

  • Dural Tear or Cerebrospinal Fluid Leak:

  • Damage to the dura (the covering of the spinal cord) can lead to cerebrospinal fluid leakage.

  • Hardware-related Issues:

  • Hardware, such as screws or plates, may break or loosen over time.

  • Blood Clots:

  • Deep vein thrombosis (DVT) or pulmonary embolism can occur.

  • Failed Fusion:

  • Fusion surgeries aim to join two vertebrae; however, fusion may not occur successfully in some cases.

  • Persistent Pain:

  • Surgery may not always alleviate pain, and some patients may experience persistent or new pain.

  • Anesthetic Complications:

  • Complications related to anesthesia, such as allergic reactions or respiratory issues.

  • Instrumentation Issues:

  • Problems with implanted devices, such as rods or screws.

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