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Anti-aging effects of mesenchymal stem cells Revival Clinic Bangkok

With what we know of stem cells, it is  feasible to delay aging and improve both health and lifespan. Stem cells can play a crucial role in delaying the aging process. Stem cells, in combination with anti-aging genes, can create a sophisticated shield, which can prevent the effects of aging.

Increased wear and tear of the body’s natural stem cells, increases cellular damage, and accelerate the natural process of aging. Stem cells combined with anti-aging genes can potentially absorb the process of cellular aging. The introduction of “youthful” stem cells into the human body can rejuvenate existing cells and allow the body to age more gracefully & even reverse some effects of the aging process. As we age, our cells get sick and die. When a cell dies, it creates a cascade of events, leading to inflammation and disease that can decrease the human lifespan. 


Many environmental factors accelerate aging, such as stress, pollution, lifestyle, injuries, disease, and exposure to toxins.  Epigenetic (non-genetic influences on gene expression) changes drive aging, and reversal of these changes extend lifespan. (1) Epigenetic control of gene expression occurs by chemical modification of DNA. By choosing an active lifestyle and decreasing harmful environmental factors, aging can be delayed. 


The benefits of a stem cell transplant for aging

  • A feeling of vitality and rejuvenation 

  • Improved capacity for physical activities

  • Thickening and improved quality of hair

  • Increased libido

  • A decrease in pain

  • Increased strength, balance & overall mobility

  • Enhanced immunity 

  • Overall improvement in the quality of life

  • Immune system regulation


How stem cell therapy reduces inflammation, at a cellular level

Mesenchymal Stem cells can influence the processes of white blood cells. A macrophage is a large white blood cell that is an integral part of our immune system. Macrophages are a type of blood cell that removes infectious agents and dead cells from the blood that can create inflammation (M1) and reduce inflammation (M2). 

M1 macrophages are associated with accelerated aging, and M2 macrophages are associated with anti-aging. Mesenchymal stem cells shift M1 macrophages to M2. They are, therefore, giving the human body more tools to combat the natural aging process by significantly reducing inflammation.


Stem cells can maintain mitochondrial health

Cord tissue-derived mesenchymal stem cells also maintain mitochondrial health (the powerhouse of the cell) by intercellular communication through tunneling nanotubes. This system senses the mitochondrial status of patient’s cells and physically transfers mitochondria from stem cells to unhealthy cells. 

Stem cell anti aging, how our cells age

Aging is a complex, natural process; the effect of environmental factors, genetics, and routine wear and tear on the bodies eventually takes a toll in a multitude of different ways. It is this result of living life that can bring unavoidable health problems. Over time, the cells of the body age as we do, resulting in their inability to replicate; they become damaged and die. The loss of efficient cell replication is what causes our bodies to age. Revival Clinic Bangkok


Homing properties (how MSCs know where to go)

One of the key benefits of mesenchymal stem cells is their ability to target specific areas of concern due to their intrinsic homing capabilities.  Mesenchymal stem cell homing, when administered systemically can be defined as exiting circulation and migrating to the injury site.

Systemic homing is a multistep process governed by specific molecular interactions. "The process of systemic homing can be split into five steps: (1) tethering and rolling, (2) activation, (3) arrest, (4) transmigration or diapedesis, and (5) migration.


Differentiation (becoming new types of cells)

Mesenchymal stem cells are multipotent stem cells that can self-renew and differentiate into different cell types. In other words, mesenchymal stem cells can become a variety of different cell types including; adipose tissue, cartilage, muscle, tendon/ligament, bone, neurons, and hepatocytes "The differentiation of MSCs into specific mature cell types is controlled by various cytokines, growth factors, extracellular matrix molecules, and transcription factors (TFs).

Mesenchymal stem cells contribute to tissue regeneration and differentiation, including the maintenance of homeostasis and function, adaptation to altered metabolic or environmental requirements, and the repair of damaged tissue.


Conclusion

There is a plethora of research surrounding the mechanisms of mesenchymal stem cells (MSCs).  Many studies have outlined their diversified capabilities including self-renewal, immunomodulatory, anti-inflammatory, signaling, and differentiation properties.  These characteristics enable MSCs to be used in a variety of clinical settings for multiple degenerative conditions.  

Research is starting to suggest that umbilical cord tissue-derived MSCs (UC-MSCs) are more potent than other sources of mesenchymal stem cells thus potentially increasing their clinical efficacy.

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