MOTS-c

MOTS-c Peptide Therapy

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a mitochondrial-derived peptide studied for its role in metabolic regulation, insulin sensitivity, and cellular energy balance. Unlike many peptides, MOTS-c is encoded by mitochondrial DNA and is closely linked to mitochondrial function and metabolic health.

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At our clinic, MOTS-c is sourced from the USA, supplied with a Certificate of Analysis (COA), and prescribed under licensed doctor supervision to ensure safety, correct dosing, and appropriate injection technique.

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Why choose our clinic

• USA product with COA: Verified purity, identity, and quality

• Doctor-supervised protocol: Individual assessment and monitoring

• Complete injection kit provided: Vials, sterile water, insulin syringes/needles, alcohol swabs, and written instructions

• Affordable pricing: Transparent, professional peptide therapy

 

Potential benefits 

• Metabolic health and energy regulation

• Improved insulin sensitivity

• Fat metabolism and glucose utilization

• Mitochondrial function

• Exercise capacity and metabolic resilience

• Healthy aging support

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Product & dosing protocol 

Product format

• MOTS-c: 5 mg vial

• Reconstitution: 0.5 mL sterile water per vial

• Route: Subcutaneous (SC) injection

• Syringe: Insulin syringe

Typical dosing (as prescribed)

• Inject 1 mL subcutaneously once weekly

• Each injection requires 2 vials
  (Total dose per injection = 10 mg MOTS-c)

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How to prepare & inject

1) Reconstitute the peptide (one time per vial)

Inject 0.5 mL of sterile water into each MOTS-c vial using a syringe. Direct the liquid gently down the inside wall of the vial. Swirl gently until fully dissolved. Do not shake. Label each vial with the date and time mixed.

2) Prepare the weekly dose

For each weekly injection, combine the full contents of 2 reconstituted vials to reach a total injection volume of 1 mL, as instructed by your clinician.

3) Subcutaneous injection

Using an insulin syringe, inject 1 mL subcutaneously (abdomen preferred). Rotate injection sites weekly to minimize irritation.

4) Storage

Store reconstituted vials in the refrigerator (2–8°C) and protect from light. Use only as directed by your healthcare provider.

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Possible side effects

MOTS-c is generally well tolerated in reported studies. Possible side effects may include:

• Mild injection-site discomfort

• Temporary fatigue

• Headache or light dizziness

• Transient flu-like symptoms (rare)

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Contraindications & precautions

MOTS-c may not be appropriate for everyone. Consult your doctor before use if you have:

• Pregnancy or breastfeeding

• Active cancer or undergoing chemotherapy

• Severe or uncontrolled diabetes

• Significant liver or kidney disease

• Known hypersensitivity to peptide products

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Drug interactions

There are no well-established drug interaction studies for MOTS-c. Inform your clinician if you are taking:

• Insulin or glucose-lowering medications

• Metformin or other metabolic agents

• Hormone therapies

• Other injectable peptides

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Common questions (FAQ)

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Why are two vials needed per injection?

Each vial contains 5 mg. The prescribed 10 mg weekly dose requires two vials combined into one injection.

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Do you provide injection supplies?

Yes. We provide a complete injection kit. Additional supplies are available if needed.

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References 

• Lee C, et al. MOTS-c: A mitochondrial-derived peptide regulating metabolic homeostasis

• Reynolds JC, et al. MOTS-c improves insulin sensitivity and metabolic function

• Zarse K, et al. Mitochondrial peptides and aging metabolism

• Kim KH, et al. MOTS-c and exercise-induced metabolic adaptation